Status:
COMPLETED
Study on the Influence of Electroconvulsive Therapy (ECT) on Homocysteine Levels
Lead Sponsor:
University of Erlangen-Nürnberg Medical School
Conditions:
Depressive Disorder, Major
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Elevated homocysteine levels are associated with depression and cognitive impairment. When depression ameliorates due to treatment, homocysteine serum levels often normalize. Aim of the present study ...
Detailed Description
BACKGROUND: Elevated homocysteine levels have been found in depressive disorders. The modulating effects of homocysteine on glutamatergic neurotransmission have been discussed to be an underlying cau...
Eligibility Criteria
Inclusion
- Key
- Men and women aged 18 years or above
- Diagnosis of major depressive disorder (according to DSM IV)
- Secured therapy resistance (at least two trials with antidepressive medication of different classes for more then 4 weeks in adequate dosage)
- Written, informed consent
- Key
Exclusion
- Major neurological or other diseases
- Current medication with antiepileptic drugs
- History of major head trauma
- Any medical condition not allowing anesthesia
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2007
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00370058
Start Date
August 1 2006
End Date
August 1 2007
Last Update
December 14 2020
Active Locations (1)
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1
Department of Psychiatry and Psychotherapy, University Erlangen-Nuremberg
Erlangen, Germany, 91054