Status:
WITHDRAWN
Topiramate on Gambling-Related Behaviours
Lead Sponsor:
Centre for Addiction and Mental Health
Conditions:
Gambling
Eligibility:
All Genders
19-65 years
Phase:
PHASE2
Brief Summary
The quest for an effective medication therapy for problem gambling remains an important priority for the problem gambling treatment research field. While several medications have been evaluated in con...
Detailed Description
The quest for an effective pharmacotherapy for problem gambling remains an important priority for the problem gambling treatment research field. While several medications have been evaluated in contro...
Eligibility Criteria
Inclusion
- 19 - 65 years of age either gender
- plays electronic gaming machines (e.g. slot machine, video poker)
- meets DSM IV criteria for pathological gambling
Exclusion
- females pregnant or breastfeeding at study entry
- females of childbearing age and physically able to conceive but not on oral contraceptives or patch, unwilling to take pregnancy self-test before each test session
- females taking oral contraceptives or patch but unwilling to use a barrier method of contraceptive during the course of the study
- occupation involving driving or operating heavy machinery
- BMI \< 20
- hepatic dysfunction or hepatitis, as indicated by elevated INR, low serum albumin, or high bilirubin, or elevated AST, ALT, GGT (\>1.5 times normal)
- clinical evidence of cirrhosis on examination
- renal insufficiency (creatinine \>150)
- history of renal stones
- history of glaucoma
- current seizure disorder
- current use of digoxin
- current use of benzodiazepines
- alcohol consumption \>14 drinks /week
- current use of anti-seizure medications (phenytoin, carbamazepine, valproic acid, primadone), antipsychotic medications (e.g., seroquel), carbonic anhydrase inhibitors (acetazolamide), metformin
- diagnosis of Axis I disorders, including psychoactive substances disorders (except nicotine)
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00370188
Start Date
September 1 2006
Last Update
July 22 2015
Active Locations (1)
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1
Centre for Addiction and Mental Health
Toronto, Ontario, Canada, M5S 2S1