Status:
COMPLETED
Effect of Ipratropium on Acute Bronchitis in Subjects Without Underlying Lung Disease
Lead Sponsor:
Kaiser Permanente
Conditions:
Bronchitis
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
ABSTRACT CONTEXT: Inappropriate antibiotic prescriptions for acute bronchitis is a major public health concern because of antibiotic resistance. Effective therapies for managing the symptoms of acute ...
Detailed Description
METHODS COUGH STOP was an investigator-initiated study. We conducted a prospective, randomized, double blind, placebo controlled trial to test the hypothesis that ipratropium would improve cough symp...
Eligibility Criteria
Inclusion
- cough with or without sputum production for less than 30 days duration; were age 18 through 65; and were willing to follow up by phone for a brief interview at 2, 4, and 8 days after enrollment
Exclusion
- history of COPD; asthma; or other lung disease; had localized lung findings on exam to suggest pneumonia or asthma; chest X-ray (if done) with evidence of pneumonia; purulent nasal discharge or other evidence of bacterial sinus infection; evidence of streptococcal pharyngitis; temperature greater than 101.5 in the preceding 72 hours; treatment of a respiratory tract infection in the last 30 days; pregnancy; breast feeding; actively trying to become pregnant; history of heart failure; history of renal failure or insufficiency with a creatinine greater than 2.0 mg/dl; history of psychiatric illness other than minor depression; currently incarcerated; or were unwilling to sign the consent form.
Key Trial Info
Start Date :
October 1 2002
Trial Type :
INTERVENTIONAL
End Date :
January 1 2004
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00371527
Start Date
October 1 2002
End Date
January 1 2004
Last Update
October 17 2008
Active Locations (1)
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1
South Sacramento Kaiser Permanente
Sacramento, California, United States, 95823