Status:
COMPLETED
Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine in Lung Fluid of Adults With and Without HIV Infection
Lead Sponsor:
Royal Liverpool University Hospital
Collaborating Sponsors:
Kamuzu University of Health Sciences
Liverpool School of Tropical Medicine
Conditions:
Pneumonia
Meningitis
Eligibility:
All Genders
17+ years
Phase:
PHASE4
Brief Summary
Lung immune responses are regulated independently of systemic responses. Injected vaccines may induce optimal responses in blood but not at mucosal surfaces. We compared the responses in serum and lun...
Detailed Description
We tested the hypothesis that conjugate vaccine offered less protection against pneumonia due to a reduced mucosal response compared to serum. We further hypothesized that this response would be furth...
Eligibility Criteria
Inclusion
- healthy volunteer adults
Exclusion
- pregnant, recent illness, previous vaccination, asthma
Key Trial Info
Start Date :
February 1 2003
Trial Type :
INTERVENTIONAL
End Date :
October 1 2003
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00371878
Start Date
February 1 2003
End Date
October 1 2003
Last Update
August 8 2008
Active Locations (1)
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1
Wellcome Trust Laboratories and Dept of Medicine, Queen Elizabeth Central Hospital
Blantyre, Malawi, BT3