Status:

COMPLETED

PALUREA: Severe Imported Malaria in Adults

Lead Sponsor:

Assistance Publique - Hôpitaux de Paris

Collaborating Sponsors:

Institut National de la Santé Et de la Recherche Médicale, France

Conditions:

Malaria

Eligibility:

All Genders

18+ years

Brief Summary

Plasmodium falciparum malaria remains a major public health problem in endemic areas, with approximately 2 million deaths each year, especially in tropical African countries. In non-endemic industria...

Detailed Description

Plasmodium falciparum malaria remains a major public health problem in endemic areas, with approximately 2 million deaths each year, especially in tropical African countries. In non-endemic industria...

Eligibility Criteria

Inclusion

  • Inclusion Criteria in Severe Malaria Group:
  • Hospitalization in the ICU and
  • Presence of asexual forms of Plasmodium falciparum in the blood and
  • One or more severe manifestations according to the World Health Organization (WHO) definition of severe falciparum malaria published in 2000
  • Inclusion Criteria in Uncomplicated Malaria Group:
  • Hospitalization in Medicine unit or ambulatory and
  • Presence of asexual forms of Plasmodium falciparum in the blood and
  • Absence of any severe manifestation according to the WHO definition of severe falciparum malaria published in 2000 with the exception of the criteria hyper parasitaemia (superior4%) when isolated or the criteria jaundice /total bilirubin superior 5 micromol/L when isolated

Exclusion

  • Patient \< 18 years-old
  • Impossible to obtain informed consent
  • Curative treatment of malaria for more than 72 hours

Key Trial Info

Start Date :

September 1 2006

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

March 1 2010

Estimated Enrollment :

302 Patients enrolled

Trial Details

Trial ID

NCT00372684

Start Date

September 1 2006

End Date

March 1 2010

Last Update

June 22 2010

Active Locations (1)

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1

Ch Versailles

Le Chesnay, France, 78150