Status:
COMPLETED
Does the Threat of an Aversive Reaction Affect Craving of Alcohol During Cue Exposure in Alcohol Dependent Patients?
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Institut de Recherches Scientifiques sur les Boissons
Conditions:
Alcoholic Intoxication, Chronic
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To evaluate the effect of the threat of an aversive reaction on the response during alcohol cue exposure in alcohol dependent patients : (1) the subjective response (craving) and (2) the physiological...
Detailed Description
The efficacy of disulfiram in relapse prevention is controversial. Not only are most of the studies dated but their methodological rigor is generally poor. The major obstacle to disulfiram's effective...
Eligibility Criteria
Inclusion
- Inpatients
- Alcohol dependence
- Detoxified since at least one week
- Willing to abstain from alcohol for at least 6 months
- Never treated with disulfiram
Exclusion
- Any contra-indication to disulfiram
- Treated with and antidepressant or a neuroleptic medication within the 30 previous days
- Treated with acamprosate, naltrexone, betablockers or clonidine within the 7 previous days
- Treated with benzodiazepines within the 3 previous days (except diazepam, maximum 30 mg/d)
- Anosmia
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00372749
Start Date
October 1 2006
End Date
March 1 2009
Last Update
March 28 2011
Active Locations (1)
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1
Hopital Emile Roux APHP
Limeil-Brévannes, France, 94450