Status:

TERMINATED

Refractory Urge Incontinence and Botox Injections

Lead Sponsor:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Conditions:

Urinary Incontinence

Detrusor Overactivity

Eligibility:

FEMALE

21+ years

Phase:

PHASE3

Brief Summary

The purpose of this study is to see whether Botox A (injected into the bladder muscle) can improve symptoms of urge incontinence that has not improved with usual medical treatments.

Detailed Description

Women who suffer with urge incontinence may not get relief with usual medical treatment (such as medications or behavioral techniques). We plan to enroll women with refractory urge incontinence in cen...

Eligibility Criteria

Inclusion

  • Adult women
  • Detrusor overactivity incontinence confirmed by urodynamic testing
  • Symptoms refractory to standard first- and second-line treatments
  • 6 or more urge incontinence episodes on 3-day bladder diary
  • Normal neurological examination

Exclusion

  • Urinary retention
  • Allergy to Botox (Botulinum Toxin A)
  • Previous bladder treatment with Botox (Botulinum Toxin A) in the past year
  • Pregnancy or planning pregnancy within next year
  • Neurologic disease with impaired neurotransmission

Key Trial Info

Start Date :

June 1 2006

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 1 2007

Estimated Enrollment :

87 Patients enrolled

Trial Details

Trial ID

NCT00373789

Start Date

June 1 2006

End Date

December 1 2007

Last Update

January 11 2011

Active Locations (8)

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Page 1 of 2 (8 locations)

1

University of Alabama

Birmingham, Alabama, United States, 35249

2

USCD Medical Center

La Jolla, California, United States, 92037

3

Kaiser Permanente

San Diego, California, United States, 92120

4

Loyola University

Maywood, Illinois, United States, 60153