Status:
COMPLETED
A Study on Immunological Effect of Vitamin A and Zinc in a Placebo Controlled 4 Cell Trial
Lead Sponsor:
International Centre for Diarrhoeal Disease Research, Bangladesh
Conditions:
Immunity
Diarrhea
Eligibility:
All Genders
1-3 years
Phase:
NA
Brief Summary
Vitamin A deficiency in children is associated with increased mortality and morbidity due to respiratory tract and diarrhoeal infections. Vitamin A supplementation has been shown in some studies to re...
Detailed Description
Immunological indicators will be monitored at the beginning and after 8 weeks of giving vitamin A or zinc in a double blind randomized trial. A clinical based study will be done to see the effect of z...
Eligibility Criteria
Inclusion
- Children aged between 1 and 3 years having weight for age between 70% and 61% of NCHS standard.
- Who come to the out patient department of ICDDR,B for treatment of acute water diarrhoea with
- No signs of vitamin A deficiency (non invasive diarrhoea and without systematic infection) and has not received vitamin A during last 4 months.
- Who has not received measles vaccine and did not have measles primarily identified for the study.
- Children who has not reside in and around Dhaka city
Exclusion
- Children who needs immediate vitamin A supplementation (clear sign of vitamin deficiency)
- Children who received vitamin A within the last 4 months
- Children with other systematic infection
- Subjects who develop any kind of sign and symptoms of vitamin A deficiency will be given vitamin A and will be analysed separately
Key Trial Info
Start Date :
July 1 1993
Trial Type :
INTERVENTIONAL
End Date :
November 30 1995
Estimated Enrollment :
147 Patients enrolled
Trial Details
Trial ID
NCT00374023
Start Date
July 1 1993
End Date
November 30 1995
Last Update
November 28 2017
Active Locations (1)
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1
Dhaka Hospital, ICDDR,B
Dhaka, Bangladesh, 1212