Status:
UNKNOWN
Therapy With Verapamil or Carvedilol in Chronic Heart Failure
Lead Sponsor:
Medical University of Silesia
Conditions:
Dilated Cardiomyopathy
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The aim of this study is to compare the effect of treatment with verapamil or carvedilol on long-term outcomes in stable, chronic heart failure secondary to non-ischemic cardiomyopathy.
Detailed Description
Heart failure, irrespective of its etiology may be viewed as a progressive disorder initiated by a different events and sustained by a multifaceted pathophysiological mechanisms. Regardless of the nat...
Eligibility Criteria
Inclusion
- Chronic heart failure (NYHA II and III; LV ejection fraction, ≤ 35%) secondary to non-ischemic cardiomyopathy
- Stable condition at least 6 months before enrollment on conventional therapy (beta-blockers, ACE inhibitors and diuretics).
Exclusion
- Improvement in clinical status on conventional therapy in out-patients period preceded hospitalization,
- Any changes narrowing epicardial coronary arteries in coronary angiography,
- Insulin dependent diabetes,
- Valvular heart disease (except the relative mitral regurgitation),
- Endocrine disease
- Significant renal and liver disease
- Alcohol abuse
- Lack of written informed consent
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
End Date :
May 1 2008
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00374465
Start Date
January 1 2006
End Date
May 1 2008
Last Update
September 11 2006
Active Locations (1)
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1
Silesian Centre for Heart Disease, 3rd Department of Cardiology
Zabrze, Szpitalna 2 Saint, Poland, 41800