Status:
WITHDRAWN
HERMES STUDY: Study on the Feasibility and Efficiency of Noninvasive Positive-Pressure Ventilation (NPPV) in Prehospital Care
Lead Sponsor:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Collaborating Sponsors:
Frederic Thys,MD,PhD
Conditions:
ARF Secondary to COPD Exacerbation
ARF Secondary to Cardiogenic Acute Pulmonary Oedema
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is determine if NPPV can be performed in a pre-hospital setting very early after onset of dyspnea with a similar benefit in need of intubation and mortality as in previous st...
Detailed Description
Noninvasive positive-pressure ventilation (NPPV) is increasingly being used in the care of patients suffering acute respiratory failure. High-level evidence supports the use of NPPV in this setting. W...
Eligibility Criteria
Inclusion
- Out-of-hospital patients with acute respiratory failure
- only patients with COPD, APO are included.
- Patients are eligible into the study if the attending physician judged that the need of a mechanical ventilatory support is imminent.
- Patients not improving under usual treatment
Exclusion
- An immediate indication for endotracheal intubation (respiratory and/or cardiac arrest).
- Major unrest.
- Hemodynamic instability despite a fluid challenge (500 ml of colloids).
- Facial or thoracic trauma.
- Lack of cooperation.
- Difficult adaptation of facial mask to patient's facial anatomy.
- Clinical suspicion of pulmonary embolism.
- Retrosternal pain suggestive of a myocardial ischemia
- If the investigators are not available.
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00375154
Start Date
August 1 2006
Last Update
July 20 2011
Active Locations (8)
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1
Emergency Department; Cliniques Universitaires Saint-Luc
Brussels, Belgium, B1200
2
CHU Brugman-Schaerbeek
Brussels, Belgium
3
Hôpital de Dinant
Dinant, Belgium
4
Cliniques Notre Dame de Gosselies
Gosselies, Belgium