Status:
UNKNOWN
Risk Factors Associated With Calcification of the Aortic Valve
Lead Sponsor:
Charles University, Czech Republic
Conditions:
Aortic Stenosis
Aortic Sclerosis
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is * to determine the degree of endothelial dysfunction and inflammation in calcific aortic valve disease associated with coronary artery disease(CAD). * to determine whethe...
Detailed Description
Cardiovascular disease, mainly coronary artery disease, causes more than one half of deaths in the developed countries. Only recently, calcific aortic valve disease, was proved to belong to the family...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- significant stenosis (more than 50% diameter stenosis) of one or more coronary arteries
- aortic sclerosis (group 1) or stenosis (AVA \< 1cm2/m2, or mean gradient ≥ 30 mmHg) (group 2) or normal aortic valve (group 3)
- Exclusion criteria:
- Rheumatic heart disease (defined as aortic stenosis with commissural fusion + rheumatic mitral valve disease)
- Status post aortic valve replacement
- Congenital complex heart disease (except bicuspid aortic valve)
- Moderate to severe aortic insufficiency (grade \> 2/4)
- Marfan syndrome
- Infective endocarditis
- Hypertrophic obstruction cardiomyopathy
- Acute coronary syndrome within less than three months
- Severe heart failure, NYHA class IV
- Severe locomotion disability
- Renal failure requiring dialysis
- Significant systemic disease or other disease severely limiting the patient prognosis (e.g. known cancer, liver cirrhosis)
- Primary hyperparathyroidism
- Patient non-compliance
Exclusion
Key Trial Info
Start Date :
January 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2008
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00375336
Start Date
January 1 2005
End Date
December 1 2008
Last Update
January 1 2009
Active Locations (1)
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1
Charles University of Prague, School of Medicine, Plzen
Pilsen, Czechia, 304060