Status:
COMPLETED
Niacin Flushing as Marker of Cannabis Effects on Arachidonic Acid Pathways in Schizophrenia
Lead Sponsor:
University of Jena
Conditions:
Schizophrenia
Cannabis Abuse
Eligibility:
All Genders
18-40 years
Brief Summary
Increasing evidence suggests modulating effects of cannabinoids on time of onset, severity, and outcome of schizophrenia. Efforts to discover the underlying pathomechanism have led to the assumption o...
Detailed Description
Subjects Niacin skin tests are performed on acutely ill consecutively admitted schizophrenia patients suffering not more than two psychotic episodes. All meet DSM-IV criteria for paranoide schizophren...
Eligibility Criteria
Inclusion
- Patients:
- acutely ill
- consecutively admitted
- diagnosis of schizophrenia according to DSM-IV criteria for paranoide schizophrenia.
- not treated or treated with atypical neuroleptic drugs
- cannabis use on a regular basis (≥ 0,5 g/d, at least 3 month) prior to admission or
- never use of cannabis apart from unique trials
- no use of any other drug or alcohol on a regular basis.
- Controls:
- healthy volunteers recruited by newspaper advertisement
- cannabis user (duration and dose of cannabis use as in patients)or
- no cannabis experience at all
- All cannabis consuming participants:
- positive for cannabinoids in urine test at the time of niacin testing
Exclusion
- Controls:
- current psychiatric diagnosis or psychiatric personal or family history.
- All individuals:
- any current or history of skin disorders (eczema, atopical dermatitis, psoriasis)
- recent treatment with steroids or non-steroidal antiinflammatory drugs (e.g. acetylsalicylic acid)
Key Trial Info
Start Date :
February 1 2004
Trial Type :
OBSERVATIONAL
End Date :
June 1 2005
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00376233
Start Date
February 1 2004
End Date
June 1 2005
Last Update
October 12 2006
Active Locations (1)
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1
University of Jena, Department of Psychiatry
Jena, Thuringia, Germany, D-07743