Status:
COMPLETED
Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
Lead Sponsor:
New York State Psychiatric Institute
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Dependence
Eligibility:
All Genders
21-45 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respon...
Detailed Description
Previous studies have shown that cocaine dependence is associated with a decrease in dopamine release in response to a psychostimulant challenge. We have recently completed a study demonstrating that ...
Eligibility Criteria
Inclusion
- Males or females between 21 and 45 years old
- Fulfill DSMIV criteria for cocaine abuse or dependence
- Able to give informed consent and comply with study procedures
- Medically Healthy
Exclusion
- Major DSM-IV Axis I disorder other than cocaine abuse or dependence. Subjects with a history of other psychostimulant abuse/dependence or compulsive gambling will be excluded.
- Current use of opiates, sedative-hypnotic, and/or cannabis more than twice a week (use less than twice a week is acceptable).
- Current use of psychotropic medication such as antipsychotics or antidepressants.
- Presence or positive history of severe medical or neurological illness (including epilepsy), or any cardiovascular disease, low hemoglobin (Hb \< 14 gm/dL in males, Hb \< 12 gm/dL in females), or SGOT or SGPT \> 2-3 times normal. Chronic active hepatitis B or C will also be an exclusion criteria.
- Resting SBP \>150, DBP \> 90
- Pregnancy or lactation, lack of effective birth control during 15 days before the scans\*
- Evidence /report of any heart abnormality during intake medical history, EKG or physical exam.
- Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to the guidelines set forth in the following reference book commonly used by neuroradiologists: "Guide to MR procedures and metallic objects" Shellock, PhD, Lippincott Williams and Wilkins, NY 2001.
- Lifetime exposure to radiation in the workplace, or history of participation in nuclear medicine procedures, including research protocols \*\*
- Positive Allen Test indicating lack of collateral blood flow to hand
- History of sensitivity to methylphenidate
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00376558
Start Date
July 1 2006
End Date
January 1 2011
Last Update
July 1 2016
Active Locations (1)
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1
New York State Psychiatric Institute
New York, New York, United States, 10032