Status:
COMPLETED
"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
Lead Sponsor:
Pennington Biomedical Research Center
Conditions:
Obesity
Eligibility:
All Genders
18-50 years
Phase:
PHASE2
Brief Summary
This study compares four treatments to see which one causes the most weight loss, fat loss, loss of abdominal fat and improvement in blood tests like cholesterol. The four treatments are: Placebo, Eph...
Detailed Description
The sympathetic nervous system, via the intracellular messenger cAMP and MAPK activation, and thiazolidinediones via PPARγ control lipid metabolism have been implicated in body weight regulation. The ...
Eligibility Criteria
Inclusion
- generally healthy
- not pregnant or nursing
- using adequate contraception
- between 18 and 50 years of age
- BMI between 30 and 35 kg/m2
Exclusion
- significant renal, cardiac, liver, lung or neurological disease
- high blood pressure
- diabetes
- prior use of thiazolidinedione
- prior use of beta-blockers alcohol or drug abuse
- history of thrombophlebitis, vascular or blood clotting disorders
- unwilling or unable to abstain from caffeinated beverages and alcohol prior to adipose tissue biopsy and metabolic rates measurements
- increased liver function test at baseline
- have metal objects that would interfere with the measurement of the body composition
- use drugs known to affect lipid metabolism, energy metabolism or body weight
- use herbal supplements containing ephedrine and/or caffeine
- take chronic medication, except hormone replacement or contraception
- are a woman unwilling to use effective contraception during the trial
- have heart disease or history of stroke
- have urinary symptoms from enlarged prostate
- have gained and or lost more than 10 pounds in the last 6 month
- have use a monoamine oxidase inhibitor medication in the last month
- have high or low thyroid function that has not been controlled in the normal range for at least 2 months
Key Trial Info
Start Date :
January 1 2003
Trial Type :
INTERVENTIONAL
End Date :
November 1 2004
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT00377975
Start Date
January 1 2003
End Date
November 1 2004
Last Update
January 25 2016
Active Locations (1)
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1
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808