Status:
COMPLETED
Effects of Pegylated Interferon Alfa-2b and Ribavirin After Orthotopic Liver Transplantation in Subjects With Chronic Hepatitis C Recurrence (P04590AM3)(COMPLETED)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Liver Transplantation
Hepatitis C, Chronic
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
This is an exploratory study and is a Phase 3, single-arm, multi-center, open-label study of pegylated interferon alfa-2b, PEG-IFN alpha-2b (PEG-Intron) and ribavirin (RBV) to determine the sustained ...
Eligibility Criteria
Inclusion
- Subjects must confirm that all prior medication washout times have been observed.
- Subject must be 18 - 70 years of age of either gender and of any race.
- Subject must be transplanted for end-stage hepatitis C or fulminant hepatitis C.
- Subject must have documented:
- persistent HCV viremia after OLT as defined by plasma positive for HCV RNA by quantitative reverse transcription-polymerase chain reaction (RT-PCR),
- A liver transplant performed at least 3 months prior to screening but not more than 3 years prior to screening.
- Subject must be on stable doses of immunosuppression for at least 1 month.
- Compensated liver disease with minimum hematologic, biochemical, and serologic criteria at the (Day 1) baseline visit.
- Alpha-fetoprotein value (AFP) less than or equal to 250ng/mL. If AFP greater than 100 ng/mL, patient will need evidence of normal liver (magnetic resonance imaging) MRI and normal chest computerized tomography (CT) scan within the last 3 months or during the screening period.
- For subjects with a history of diabetes or hypertension, clearance from an ophthalmologist has to be obtained prior to treatment start (Day 1/Visit 2).
- Subjects with a history of mild depression may be considered for entry into this study.
- Female subjects cannot be pregnant or breastfeeding and must be either postmenopausal, surgically sterile or using 2 methods of birth control.
- Sexually active male subjects are practicing an acceptable, method of contraception.
- Contraceptive measures will be reviewed with female subjects at each visit. Dual methods of contraception must be used for 1 month prior to the start of treatment and 6 months after treatment discontinuation.
- Pregnancy tests obtained at Screen Visit and Day 1 Visit prior to the initiation of treatment must be negative.
Exclusion
- Pregnant women, women who plan to become pregnant, male subjects whose partner wants to become pregnant, and breastfeeding women (during study and up to 6 months after study completion).
- Subject has used any investigational product within 30 days prior to Screening or is participating in any other clinical study.
- Prior treatment for chronic hepatitis C post-liver transplant, including but not limited to antiviral or immunomodulatory product, any interferon product, or RBV, either as monotherapy or in combination.
- Subjects with other organ transplants.
- Any subject who received a positive hepatitis C core antibody (HBcAb) or HCV positive donor liver graft.
- Retransplantation of the liver for rejection or graft failure.
- Evidence of decompensated liver disease.
- Known coagulopathies including hemophilia.
- Known hemoglobinopathies.
- Known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- Hypersensitivity to alpha interferon and/or RBV.
- Co-infection with hepatitis B virus (HBV) and/or human immunodeficiency virus (HIV).
- Evidence of active or suspected malignancy or a history of malignancy within the last 5 years (with the exception of pre-transplant hepatocellular carcinoma histologically within the Milan criteria, and adequately treated basal or squamous cell carcinoma of the skin).
- Any known pre-existing medical condition that could interfere with the subject's participation in and completion of the study.
- Subject is or was a substance abuser. Subjects treated with buprenorphine (Subutex) who have been stable for 6 months may be included.
- Patients weighing over 135 kg;
- Is participating in any other clinical study(ies);
- Is allergic to or has sensitivity to the study drug or its excipients.
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT00378599
Start Date
May 1 2006
End Date
July 1 2009
Last Update
April 6 2017
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