Status:
COMPLETED
Tranexamic Acid vs. Quixil - Reducing Blood Loss in Joint Replacement
Lead Sponsor:
Golden Jubilee National Hospital
Conditions:
Hemorrhage
Arthroplasty, Replacement, Hip
Eligibility:
All Genders
Phase:
NA
Brief Summary
We will compare the effectiveness of Quixil and Tranexamic acid in reducing bleeding during hip and knee joint replacements.
Detailed Description
This is a prospective randomised controlled trial to compare the benefits of Quixil vs. Tranexamic acid in reducing blood loss. Both medicines are used for the reduction of blood loss in major joint ...
Eligibility Criteria
Inclusion
- Patients who are to undergo elective hip or knee joint replacement
- Must be cemented arthroplasty
- Must be primary arthroplasty
Exclusion
- Uncemented arthroplasty.
- Revision arthroplasty.
- Patients on anticoagulant (warfarin, low molecular weight heparin) or other medication known to affect clotting (except aspirin, which is to be given as part of standard DVT prophylaxis in all cases).
- Other drugs that may affect the activity of the drugs under investigation.
- Allergy to asprin (all patients to receive 150mg aspirin as standard DVT prophylaxis for 6 weeks).
- Patients with known coagulopathy (APTT or PT outside normal range pre-operatively).
- Previous reaction or ethical/religious objection to receiving blood products (Quixil contains a derivative of human blood).
- Pregnancy or breastfeeding.
- Patients who have a past medical history of thrombo-embolism at any time.
- Patients who need intravenous fluid administration for greater than 24 hours following operation.
- Patients who need allogenic blood transfusion within study period.
- Jehovah's Witnesses, or any other group of patients with ethical objections to receiving blood products.
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2008
Estimated Enrollment :
132 Patients enrolled
Trial Details
Trial ID
NCT00378872
Start Date
June 1 2006
End Date
May 1 2008
Last Update
May 14 2008
Active Locations (1)
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1
Golden Jubilee National Hospital
Clydebank, Scotland, United Kingdom, G81 4HX