Status:
COMPLETED
PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
Lead Sponsor:
Danish Headache Center
Conditions:
Migraine Without Aura
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
To investigate headache score and accompanying symptoms during and after infusion of PACAP38 i migraine patients
Detailed Description
To investigate headache score and accompanying symptoms during and after infusion of PACAP38 Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood...
Eligibility Criteria
Inclusion
- Healthy migraine patient without aura
- Aged 18-50
- 50-100 kg
- Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.
Exclusion
- Tension type headache more than five times/month
- Other primary headaches
- Daily medication except contraceptives
- Drug taken within 4 times the halflife for the specific drug except contraceptives
- Pregnant or lactating women
- Exposure to radiation within the last year
- Headache within the last 48 hours before start of trial
- Hypertension
- Hypotension
- Respiratory or cardiac disease
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2007
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00380263
Start Date
November 1 2006
End Date
November 1 2007
Last Update
May 30 2008
Active Locations (1)
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1
Dansih Headache Center
Glostrup Municipality, Denmark, 2600