Status:
UNKNOWN
Early Metabolic Changes With Thiazide or Beta Blocker Therapy for Essential Hypertension
Lead Sponsor:
University of Cambridge
Collaborating Sponsors:
Cambridge University Hospitals NHS Foundation Trust
Conditions:
Essential Hypertension
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Can the oral glucose tolerance test detect changes after 4 weeks treatment with thiazide diuretics or beta blockers or combination of the two?
Detailed Description
We will be comparing the two most commonly used drugs to treat hypertension, atenolol and bendrofluazide, in patients for whom the drugs (and the doses to be used) are licenced. We propose an initial...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Volunteers will be aged 18-75 years.
- Hypertension- either
- untreated, BP 140-170/90-110
- treated for over 1 month with drugs other than beta blockers or diuretic and BP\>140/85
- treated for over 1 month with drugs other than beta blockers or diuretic and BP\<140/85 and patient willing to change medication for eight months.
- Exclusion criteria:
- Any patient already taking thiazide diuretics or beta blockers in whom these drugs cannot be switched to alternative drugs with similar or better blood pressure control.
- Any patient who is intolerant of these medications will be excluded from the study.
- Patients with gout, asthma or any other contraindications to the study drugs will be excluded.
- Women of child bearing age not using contraception.
- Volunteers with heart failure, liver failure, renal failure, terminal illnesses (e.g. cancer)
- Volunteers not able to give informed consent
- Patients with diabetes
Exclusion
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT00380289
Start Date
September 1 2006
Last Update
September 25 2006
Active Locations (1)
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1
Clinical Pharmacology Unit, Box 110, Level 3 ACCI, Addenbrookes Hospital
Cambridge, United Kingdom, CB2 2QQ