Status:
COMPLETED
Effects of Coenzyme Q10 in Progressive Supranuclear Palsy (PSP)
Lead Sponsor:
Lahey Clinic
Conditions:
Progressive Supranuclear Palsy
Eligibility:
All Genders
30+ years
Phase:
NA
Brief Summary
The clinical syndrome of PSP responds poorly to all available forms of therapy used in Parkinson's Disease (PD). Currently, no effective treatment exists. Coenzyme Q10 in high doses has been shown to ...
Detailed Description
The study is designed as a multicenter randomized, placebo-controlled, double blind trial. Up to 60 patients with PSP will be enrolled at several centers in the United States
Eligibility Criteria
Inclusion
- Patients fulfilling the diagnostic criteria of PSP/diagnosed within the past 5 years
- Either vertical supranuclear palsy or both slowing of vertical saccades
- Prominent postural instability with falls in the first year of disease onset
- No evidence of other diseases that could explain the foregoing features
Exclusion
- Current or previous therapeutic use of CoQ10
- Parkinsonism due to drugs
- History of pallidotomy, thalamotomy, active deep brain stimulator or fetal tissue transplant
- History of active epilepsy, stroke, structural brain disease
- Use of methylphenidate hydrochloride, cinnarizine, reserpine, amphetamines, or monoamine oxidase-A inhibitors within 3 months before the baseline visit.
- Active cancer or cancer undergoing treatment
- Participation in other drug studies or the use of other investigational drugs within 30 days before screening.
- Known hypersensitivity to Coenzyme Q10.
- Pregnant, planning a pregnancy or nursing woman
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT00382824
Start Date
September 1 2006
End Date
January 1 2015
Last Update
August 1 2019
Active Locations (3)
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1
University of Alabama
Birmingham, Alabama, United States, 35294
2
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
3
Lahey Clinic
Burlington, Massachusetts, United States, 01805