Status:
COMPLETED
Endothelial Dysfunction As A Predictor Of Perioperative Outcome
Lead Sponsor:
M.D. Anderson Cancer Center
Conditions:
Endothelial Dysfunction
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this clinical research study is to learn whether the inability of certain blood vessel cells (endothelial cells) to function properly may help researchers to predict who is at risk for com...
Detailed Description
A small group of patients (about 12 out of every 100) are at risk of developing complications, for example lung infection, after their surgery. Researchers do not always know which patient is at risk ...
Eligibility Criteria
Inclusion
- Patients scheduled for major thoracic surgery (lobectomy, pneumonectomy, esophagectomy).
- Patients 18 years of age or older.
- Patients who have signed the consent form to participate in the study.
- Patients must have been evaluated in the Preanesthesia Clinic or by a staff Anesthesiologist preoperatively.
- All laboratory and diagnostic evaluations required or used to evaluate the patient in the Preanesthesia Clinic must be completed. All patients must be approved for surgery by the standards of the Preanesthesia Clinic.
Exclusion
- Refusal to participate in the study.
- Patient is under age 18.
- Patient is unwilling to sign consent.
- Patient is unable to exercise (bedridden or wheel chair bound).
- Patient is enrolled in another study deemed by the investigator to affect oxygen metabolic efficiency and not presently the standard of care at MDACC.
- Any patient whose condition is deemed unsatisfactory for surgery after the preanesthetic evaluation.
- Surgery canceled for any reason. The patient may reenter the study if surgery is rescheduled.
- Patient has had a myocardial infarction within 3 months of visiting the Preanesthesia Clinic or presents with new or unstable angina.
- Patient has a history of cerebrovascular accident or transient ischemic attacks within 3 months of visiting the Preanesthesia Clinic.
- Patient has a history of pulmonary embolic event within 3 months of visiting the Preanesthesia Clinic.
- Patient known to have acute or chronic deep vein thrombosis.
- Pregnant patients.
Key Trial Info
Start Date :
March 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 5 2019
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00384683
Start Date
March 1 2006
End Date
June 5 2019
Last Update
September 24 2019
Active Locations (1)
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1
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030