Status:
COMPLETED
To Compare the Ischemic Pre-conditioning and Post-conditioning on Reperfusion Injury in Humans.
Lead Sponsor:
Emory University
Conditions:
Endothelial Dysfunction
Eligibility:
All Genders
15-35 years
Brief Summary
Reperfusion Injury occurs by the sudden blood flow to the injured and ischemic myocardium during restoration of blood flow either by Mechanical revascularization or thrombolysis. A phenomenon known as...
Detailed Description
Myocardial ischemia is one on the leading causes of mortality and morbidity in the United States. The initial injury to the myocardium is due to a state of imbalance when oxygen demand exceeds supply....
Eligibility Criteria
Inclusion
- Male and female volunteers between the ages of 18 and 35.
- Able to give informed and witnessed consent.
- Don't have the following risk factor
- Non smoker
- LDL\<180, HDL\>30, TG\<200 or LDL/HDL\<6.0
- Does not have diabetes mellitus .
- BP \< 135/85
- Do not have family history defined as a parent or sibling with coronary disease diagnosed before age 40. .
Exclusion
- Patients with significant medial illness for which they are receiving continued monitoring or treatment, known cardiovascular disease, or risk factors for coronary artery disease are excluded. These risk factors include
- Smoking
- Hyperlipidemia defined as and LDL\>180, HDL\<30, TG\>200 or LDL/HDL\>6.0
- Diabetes mellitus
- Hypertension,
- Strong family history defined as a parent or sibling with coronary disease diagnosed before age 40.
- The exclusion criteria are to prevent the confounding effects of atherosclerosis or other medical conditions in our study.
Key Trial Info
Start Date :
May 1 2006
Trial Type :
OBSERVATIONAL
End Date :
August 1 2006
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00385151
Start Date
May 1 2006
End Date
August 1 2006
Last Update
November 18 2013
Active Locations (1)
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1
Emory University Hospital
Atlanta, Georgia, United States, 30322