Status:
UNKNOWN
A Study Evaluating Potential Screening Tools for Detecting Parkinson Disease
Lead Sponsor:
Institute for Neurodegenerative Disorders
Collaborating Sponsors:
United States Department of Defense
Molecular NeuroImaging
Conditions:
Parkinson Disease
Eligibility:
All Genders
50+ years
Phase:
PHASE2
Brief Summary
This study is designed as a prospective cohort study to test the strategy of combining two biomarkers of parkinsonism, olfaction and brain imaging with a radioactively labeled drug, \[123I\]β-CIT , in...
Detailed Description
First-degree relatives that agree to participate (n=3,000) will be asked to complete a 40-item olfactory identification test provided by mail. 300 subjects (225 with decreased odor identification and ...
Eligibility Criteria
Inclusion
- At Risk -
- subject must have a first-degree relative with PD, based on their report
- subject must not carry a diagnosis of PD or other neurodegenerative disorder.
- subject must be either at least 50 yrs old or within 10 yrs of the age of onset of their affected relative
- Subject must have no other known reason for abnormal olfaction (e.g. nasal trauma, sinus infection, sinus surgery)
- Subject must not be pregnant if participating in the imaging portion of this study
- Non-First Degree Relative -
- Subject must not carry a diagnosis of PD or other neurodegenerative disorders
- Subject must have no other known reason for abnormal olfaction (e.g. nasal trauma, sinus infection, sinus surgery)
- Subject must not be pregnant or be an actively nursing mother if participating in the imaging portion of this study.
Exclusion
- diagnosis of PD or other neurodegenerative disorder
- other known reason for abnormal olfaction (e.g. nasal trauma, sinus infection, sinus surgery)
- pregnancy, if participating in the imaging portion of this study
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2023
Estimated Enrollment :
3000 Patients enrolled
Trial Details
Trial ID
NCT00387075
Start Date
November 1 2006
End Date
August 1 2023
Last Update
March 29 2022
Active Locations (1)
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1
Institute for Neurodegenerative Disorders
New Haven, Connecticut, United States, 06510