Status:
COMPLETED
Adipose Tissue Involvement in Alcohol-induced Liver Inflammation in Human
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Alcoholic Hepatitis
Alcoholic Cirrhosis
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The histological characteristics of alcoholic liver disease (ALD) and non-alcoholic steatohepatitis (NASH) related to overweight and obesity suggest the presence of partly common physiopathological me...
Detailed Description
The aim of this project is to demonstrate that ADIPOKINES, as well as the PPAR alpha and gamma are implied in the intensity of the steatosis and in the regulation of the inflammatory process and the h...
Eligibility Criteria
Inclusion
- Alcoholic patients of both sex aged from 18 to 75, hospitalized for alcoholic liver disease.
- HBs antigen negative, HIV negative, anti -VHC negative
- daily consumption exceeded 40-50 grams per day during the last year
- elevated AST level and liver biopsy during the hospitalisation Patients who signed the informed consent document
- patients affiliated to the national health insurance system
Exclusion
- patients having another cause than alcohol for liver injury
- hepatocellular carcinoma or another developing cancer, severe associated pathology (cardiac disease, respiratory insufficiency, severe psychiatric problems), pancreatitis, infection, diabetes or a dyslipidemia
- patients treated with fibrates or other hypolipidaemic drugs, oral antidiabetics or insulin
- patients having hemostasis which does not permit the TRANSCOSTAL liver biopsy, platelet level \<60 giga/l, or Quick test \< 50 %, or (TCA higher than 1,5 times the time of the witness)
- patients refuse an adipose tissue biopsy
- patients treated with long-duration dose of clopidogrel (Plavix®)
- patients who significantly diminished alcohol consumption in comparison with the average consumption during the year preceding the inclusion
- patients not-affiliated to the national health insurance system
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT00388323
Start Date
November 1 2006
End Date
January 1 2011
Last Update
December 11 2012
Active Locations (1)
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1
Hôpital Antoine Béclère
Clamart, France, 92140