Status:
COMPLETED
Normal Control Cohort Sample Bank
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
GlaxoSmithKline
Conditions:
Healthy
Eligibility:
All Genders
18-45 years
Brief Summary
This study is designed to collect lung washing samples and small pieces of tissue (biopsies) from the lungs of people who do not have any allergies or asthma. These samples will be used by researchers...
Detailed Description
Participants in this study must be between the ages of 18 and 45 years and have no general health concerns and do not have allergies or asthma. If qualified, participants will come to the study site u...
Eligibility Criteria
Inclusion
- A subject is eligible for participation in the study if all of the following criteria apply:
- Ability to give a valid informed consent to participate by signing and dating a written consent form.
- Male or female with no chronic or acute health concerns that might affect subject safety during the study or interfere with the study results, 18-45 years of age
- An FEV1 \> 80% of predicted with an FEV1/FVC ratio above 0.70
- Methacholine PC20 \>16 mg/ml
- Skin test negative to panel of 12 common aeroallergens
Exclusion
- A subject is not eligible to participate in this study if any of the following criteria apply:
- Medications other than for contraception or OTC pain medications to be approved by PI
- Recent smoker (within 5 years) or has a smoking history exceeding 5 pack years
- Currently participating in another clinical trial or has participated in an investigational drug trial with in one month of the screening visit
- Unable, in the judgment of the investigator, to comply with directions and/or tolerate the procedures required for participation in this trial,
- Pregnant or breast-feeding or has a planned pregnancy during the course of the study
- History of bleeding with trauma or abnormal clotting tests
- History of allergy to any of the medications/sedatives that may be administered during the bronchoscopy procedure
Key Trial Info
Start Date :
September 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2006
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00388765
Start Date
September 1 2006
End Date
November 1 2006
Last Update
October 5 2015
Active Locations (1)
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1
University of Wisconsin
Madison, Wisconsin, United States, 53792