Status:
COMPLETED
High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM
Lead Sponsor:
International Centre for Diarrhoeal Disease Research, Bangladesh
Conditions:
Respiratory Infections
Diarrhea
Eligibility:
All Genders
6-59 years
Phase:
NA
Brief Summary
Vitamin A deficiency is an important health problem globally including Bangladesh. The problem is greater among under-five children, particularly in malnourished. Vitamin A supplementation reduces mor...
Detailed Description
Globally An estimated 140-250 million under-five children are deficient in vitamin A, which is associated with increased mortality and morbidity among this population. A relationship between the sever...
Eligibility Criteria
Inclusion
- Age 6-59 months
- Either sex
- Severe malnutrition as defined by the presence of any of the followings:
- Bipedal oedema
- Weight (measured after correction of dehydration) for height Z score \<-3 of the National Center for Health Statistics (NCHS) reference
- Written informed consent of respective parents/ guardians for participation of the children in the study.
- Children having diarrhoea (watery or invasive) or cough and cold or both for the last 48 hours.
Exclusion
- Failure to obtain consent
- Received a dose of vitamin A within the last three months
- History of night blindness or eye signs of vitamin A deficiency
- Measles or history of measles within last 8 weeks \[56\]
- Clinical suspicion of TB (evening rise of temperature, loss of appetite, gradual loss of weight, cough, night sweating) after applying modified Kenneth Jones criteria \[57\], shock other than due to hypovolaemia or hypoglycaemia, congestive cardiac failure, severe sepsis (hypothermia, tachycardia, tachypnea, hypotension) \[58\], and seizure disorders
- Trisomy-21
- Cerebral palsy
- Any other known chronic disease (e.g. hepatic, renal or congenital disorder) or malignant condition.
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
End Date :
December 31 2007
Estimated Enrollment :
260 Patients enrolled
Trial Details
Trial ID
NCT00388921
Start Date
October 1 2005
End Date
December 31 2007
Last Update
February 11 2022
Active Locations (1)
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1
Dhaka Hospital, ICDDR,B
Dhaka, Bangladesh, 1212