Status:
COMPLETED
Acetaminophen Concentration in Cerebrospinal Fluid in Infants
Lead Sponsor:
Assaf-Harofeh Medical Center
Conditions:
Fever
Eligibility:
All Genders
1-2 years
Brief Summary
Acetaminophen is the most commonly used drug in children. Inhibition of COX-3 in the brain has been suggested as the primary central mechanism by which acetaminophen decrease pain and possibly fever. ...
Detailed Description
The mechanism by which acetaminophen causes analgesia and antipyretic effect is not entirely clear. Recently a new COX isoenzyme was identified and termed COX 3. In humans this isoenzyme is most abund...
Eligibility Criteria
Inclusion
- Age: 1week - 2 years
- Rectal temperature \> 38.0OC
- A sepsis work up is indicated
- Acetaminophen was given prior to lumbar puncture (LP)
Exclusion
- Hypersensitivity to acetaminophen
- Known metabolic disorder
- Known liver or kidney disease
- Hydrocephalus
- Informed consent could not be obtained from a legal guardian
Key Trial Info
Start Date :
January 1 2004
Trial Type :
OBSERVATIONAL
End Date :
June 1 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00389454
Start Date
January 1 2004
End Date
June 1 2007
Last Update
October 31 2007
Active Locations (1)
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1
Pediatric Emergency Unit Assaf Harofeh Medical center
Ẕerifin, Israel, 70300