Status:
COMPLETED
A Study to Compare Two Different Brain Imaging Techniques in Healthy Volunteers and in Schizophrenic Patients
Lead Sponsor:
GlaxoSmithKline
Conditions:
Schizophrenia
Eligibility:
All Genders
18+ years
Brief Summary
A direct comparison of Positron Emission Tomography (PET) (11C-Raclopride) and Single Photon Emission Computed Tomography (SPECT) (123I-IBZM) D2 RO measurements would allow GSK to gain understanding o...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Not pregnant or becoming pregnant during the study.
- No abnormality in clinical examination, clinical laboratory test or ECG.
- Not taking drugs
- Patients with schizophrenia, schizophreniform disorder or schizoaffective disorders.
- Patients with at least 1 month antipsychotic monotherapy with either risperidone, olanzapine or clozapine.
- Healthy volunteers with no neurological or psychiatric illness.
- Exclusion criteria:
- Have received other antipsychotic during the last month or neuroleptics during the last year.
- If you have taken part in investigations you should not receive a radiation dose of more than 10 mSv over any 3 year period.
- History of bleeding disorder or are taking medication that affects blood clotting
- History of substance dependence (except nicotine)
- Claustrophobia
- Gross head deformity.
- Unable to lie still in the PET or SPECT camera for 1 hour and a half.
- The presence of a cardiac pacemaker or other electronic device or ferromagnetic metal foreign bodies.
Exclusion
Key Trial Info
Start Date :
December 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2007
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00392743
Start Date
December 1 2006
End Date
May 1 2007
Last Update
November 5 2012
Active Locations (7)
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1
GSK Investigational Site
Barcelona, Spain, 08003
2
GSK Investigational Site
Barcelona, Spain, 08025
3
GSK Investigational Site
Barcelona, Spain, 08035
4
GSK Investigational Site
Barcelona, Spain, 08036