Status:
COMPLETED
Enhancing Motor Task Training by Action Observation Watching Others Perform the Task
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Motor Memory
Eligibility:
All Genders
18-55 years
Brief Summary
This study will determine how the brain learns a new motor task when the subject practices the task and watches others perform it (action observation) at the same time. Healthy normal volunteers betw...
Detailed Description
Motor training (MT) elicits formation of motor memories in the human primary motor cortex. Observing another individual perform motor training (Action Observation, AO) also results in formation of mot...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age between 18-55 years
- Able to perform tasks required by the study
- Willing and able to give consent
- Possibility to obtain TMS-evoked thumb movements in a consistent direction at baseline
- EXCLUSION CRITERIA:
- Subjects are not eligible for this experiment if they:
- Are unable to perform the tasks
- Have history of severe alcohol or drug abuse, psychiatric illness like severe depression and poor motivational capacity
- Have problems with movement of the hands
- Are receiving drugs acting primarily on the central nervous system
- Are pregnant
- Have medical or technical contraindications to MRI procedures or devices producing artifacts that impair MRI signal (e.g., dental braces, pacemakers, implanted medication pumps, cochlear devices, neural stimulators, metal in the cranium, surgical clips, and other metal/magnetic implants, claustrophobia)
- Have had an allergic reaction to scopolamine. Have glaucoma, severe liver disease, kidney disease, an enlarged prostrate gland or a blocked digestive tube
- Have had an allergic reaction to dextromethorphan
- Are using a MAO inhibitor (such as Parnate \[registered trademark\], Nardil \[registered trademark\], or Marplan \[registered trademark\] or if you have used one of these drugs in the past 2 weeks
- Have asthma
- Are taking pain or arthritis medicine (sometimes called NSAIDs) such as aspirin, ibuprofen, or naproxen on a regular basis
Exclusion
Key Trial Info
Start Date :
October 18 2006
Trial Type :
OBSERVATIONAL
End Date :
July 18 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00393432
Start Date
October 18 2006
End Date
July 18 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892