Status:
COMPLETED
Efficacy and Feasibility of an Intermittent Weight Loss Program.
Lead Sponsor:
Université de Sherbrooke
Collaborating Sponsors:
Fonds de la Recherche en Santé du Québec
Conditions:
Obesity
Eligibility:
FEMALE
51-75 years
Phase:
NA
Brief Summary
The goal of the study is to measure the effect of an approach including phases of active weight loss broken by weight stabilisation periods (named intermittent weight loss) on the metabolic profile. ...
Detailed Description
Excessive levels of body fat are associated with metabolic disturbances predictive of an increased risk of coronary heart disease (CAD). It is presently unclear as to the magnitude of weight loss need...
Eligibility Criteria
Inclusion
- Women who had stopped menstruating for more than 1 year
- Waist circumference \> 90 cm
- Sedentary (\< 2 times a week of structured exercise)
- Non-smokers
- Low to moderate alcohol consumers (\< 2 drinks per day).
Exclusion
- We excluded subjects with the following conditions based on medical history and physical examination and on laboratory testing of kidney and liver functions, serum TSH, fasting glucose and lipid profile, and 75g-OGTT
- Cardiovascular disease, peripheral vascular disease or stroke
- Diabetes
- Moderate to severe hypertension (resting blood pressure \> 170/100 mm Hg);
- Body weight fluctuation \> 5 kg in the previous 6 months
- Thyroid or pituitary disease
- Hormonal replacement therapy at any time during the previous 6 months
- Medication that could affect the metabolic profile
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
End Date :
June 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00395356
Start Date
September 1 2005
End Date
June 1 2007
Last Update
November 2 2006
Active Locations (1)
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1
Institut universitaire de gériatrie de Sherbrooke
Sherbrooke, Quebec, Canada, J1H 4C4