Status:
COMPLETED
Cortisol Control of Human Inflammatory Responses to Endotoxin
Lead Sponsor:
Dartmouth-Hitchcock Medical Center
Collaborating Sponsors:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Sepsis
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The purpose of the research is to study a common and dangerous medical condition called 'septic shock' that often occurs in critically ill patients. In order to learn about septic shock in humans, we ...
Eligibility Criteria
Inclusion
- 18 \< age \< 55
- Weight \> 50 kg
- The participant is healthy, without known or suspected medical illness following routine history and physical examination and is expected to easily tolerate the clinical effects of endotoxin.
- The participant does not take any regularly scheduled medication other than thyroid replacement therapy, birth control pills, or estrogenic hormone replacement therapy.
Exclusion
- History of chronic disease of any kind such as diabetes, heart disease, cancer, HIV infection, hypertension, asthma, etc.
- History of chronic medication use other than hormone therapy as above
- History of recent acute illness within 30 days prior to study
- Inability to provide informed consent
- History of recent exposure to drugs known to alter immune function including steroids or recent infection (\< 3 months)
- Pregnancy
- History of known risk factors for HIV infection (recent multiple partners, sexually transmitted disease and unprotected sex; intravenous drug use; blood transfusion before 1985)
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2007
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00396344
Start Date
October 1 2006
End Date
November 1 2007
Last Update
May 9 2008
Active Locations (1)
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1
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756