Status:
SUSPENDED
The Effects of Pharmacotherapy on Brain Mechanisms Underlying Cocaine Dependence.
Lead Sponsor:
Hadassah Medical Organization
Conditions:
Opioid-Related Disorders
Cocaine-Related Disorders
Eligibility:
All Genders
20-50 years
Phase:
NA
Brief Summary
The overall aim of this project is to use an advanced brain imaging technique, PET, in order to monitor the progress of pharmacotherapy with modafinil or topiramate for cocaine dependence in methadone...
Detailed Description
SPECIFIC AIMS 1. To try to elucidate the brain mechanisms underlying cocaine dependence and craving in co-morbid cocaine-dependent patients. For this purpose we shall trigger craving for cocaine by e...
Eligibility Criteria
Inclusion
- Methadone-maintained cocaine-dependent patients use between 1g to 2g a day; 1 to 3 times a week
Exclusion
- use more than 2g a day; 5 times a week to everyday
- Subjects who are diagnosed as suffering from psychotic illness according to DSM-IV (Axis 1)22, or with a history of CNS disease, a history of infection that might affect CNS (HIV, syphilis, cytomegalovirus, herpes), or a history of head injury with loss of consciousness,pregnant women.
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00396734
Start Date
April 1 2007
End Date
April 1 2011
Last Update
June 10 2010
Active Locations (1)
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1
Hadassah Medical Organization
Jerusalem, Israel, 91120