Status:
COMPLETED
Motor Skill Learning in People With Parkinson's Disease
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Parkinson's Disease
Eligibility:
All Genders
21-80 years
Brief Summary
This study will compare brain changes in people with Parkinson's disease with those of normal control subjects while they learn motor skills. People with Parkinson's disease sometimes have trouble lea...
Detailed Description
Objective The aims of the present study are to: 1. Clarify that the altered plasticity of the primary motor cortex (M1) in patients with Parkinson's disease (PD) is associated with impaired motor le...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Right-handed healthy volunteers (21-80 years old)
- Idiopathic PD confirmed by either the PI or an HMCS physician to establish the diagnosis and rule out any other neurologic condition that might affect cortical plasticity.
- Patients must fulfill categories 1 to 3 of the Modified Hoehn and Yahr Scale in the 'off-medication' state.
- EXCLUSION CRITERIA:
- Subjects with a history of neurological disorder that might affect cortical plasticity including head injury with loss of consciousness and epilepsy, current use or a history of alcohol or drug abuse, psychiatric disorders requiring hospitalization, or prolonged treatment such as substance abuse addiction
- Subjects with dementia; mini mental state examination (MMSE) less than 25, frontal assessment battery (FAB) less than 13
- Subjects with other parkinsonian syndromes such as Lewy body disease, corticobasal degeneration, progressive supranuclear palsy, Binswanger disease and multiple system atrophy
- Subjects with marked tremor, dyskinesia or sensory disturbance
- Subject who have been treated with the subthalamic nucleus stimulation and pallidotomy
- Subjects who are unable to refrain from anti-parkinsonian medications for up to 15 hours on study days
- Subjects with significant hearing loss
- The following exclusion criteria are due to the use of TMS:
- Subjects with cardiac pacemakers, intracardiac lines, implanted medication pump
- Subjects with blood vessel, cochlear, or eye implants
- Subjects with increased intracranial pressure as evaluated by clinical means
- Subjects with metal in the cranium
- Subjects with dental braces (but dental fillings are okay), metal fragments from occupational exposure or surgical clips in or near the brain
Exclusion
Key Trial Info
Start Date :
November 2 2006
Trial Type :
OBSERVATIONAL
End Date :
October 3 2008
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00396942
Start Date
November 2 2006
End Date
October 3 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892