Status:
RECRUITING
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Mood Disorders
Anxiety Disorders
Eligibility:
All Genders
18-65 years
Brief Summary
This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Researchers believe that depression and anxiety disorders may cause structural and functional...
Detailed Description
Objective A major component of understanding the pathogenesis of mood and anxiety disorders is expected to involve elucidation of abnormalities in brain structure and function associated with these c...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy Controls
- Male and female subjects between 18 and 65 years of age
- Subjects must be able to give written informed consent prior to participation in this study.
- Subjects who do not currently meet and have never met criteria for any major psychiatric disorder, and who have no known first degree relatives with mood disorders.
- For cognitive experiments utilizing language stimuli only native English speakers will be enrolled.
- Major Depressive Disorder
- Male and female subjects between 18 and 65 years of age.
- Subjects have been found eligible for other ETPB research protocols according to 01-M-0254.
- Subjects must fulfill DSM-IV or V criteria for Major Depression based on clinical assessment and confirmed by a structured diagnostic interview (SCID-P).
- Subjects must be able to give written informed consent prior to participation in this study.
- For cognitive experiments utilizing language stimuli, only native English speakers will be enrolled.
- EXCLUSION CRITERIA:
- Healthy Control
- Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology, or taking any medication that is likely to influence the imaging parameters-of-interest within 3 weeks of scanning.
- Women who are pregnant are excluded from the study. Subjects will undergo pregnancy testing no more than 24 hours prior to MRI scanning.
- Subjects with contraindication to MRI scanning such as aneurysm clips, implanted neural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlear implant, or ocular foreign body.
- A history of drug or alcohol abuse within 1 year or a lifetime history of drug or alcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent).
- Major Depressive Disorder
- Presence of Axis 1 psychiatric diagnosis other than Major Depression or an Axis 2 disorder
- Subjects with major medical or neurological disorders expected to influence cognitive function or are taking any drugs likely to affect mood or cognitive function within 1 week of study participation. Depressed subjects will not be tapered/withdrawn from medications under this study.
- A history of drug or alcohol abuse within 1 year or a lifetime history of drug or alcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent).
- Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology.
- Women who are pregnant or breastfeeding will be excluded from MRI portions of the study. Subjects will undergo pregnancy testing no more than 24 hours prior to MRI scanning.
- Subjects with contraindication to MRI scanning such as aneurysm clips, implanted neural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlear implant, or ocular foreign body.
Exclusion
Key Trial Info
Start Date :
December 6 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
340 Patients enrolled
Trial Details
Trial ID
NCT00397111
Start Date
December 6 2006
Last Update
January 5 2026
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892