Status:
COMPLETED
PET Scanning of Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Volunteer
Attention Deficit Hyperactivity Disorder
Eligibility:
MALE
18-55 years
Brief Summary
This study will explore the brain in men with and without attention deficit hyperactivity disorder (ADHD). It will use positron emission tomography (PET) and magnetic resonance imaging (MRI) to study ...
Detailed Description
A. Objective Attention deficit hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder with a reported male predominance that persists into adulthood and leads to significant morbidi...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- All subjects must have normal values on screening measures to be in the study. They must be male and between 18 and 55 years of age. Primary efforts will also be to recruit non-smokers, given nicotine s ability to release dopamine presynaptically, a confound for this study. Previous smokers who have been abstinent for greater than 1 year may be considered.
- EXCLUSION CRITERIA:
- In addition to psychiatric criteria described above: past or current medical condition that would interfere with brain function - history of alcoholism, tobacco use (must have minimum of one year of full remission/complete abstinence from nicotine), neurological illness, head trauma with loss of consciousness, history of exposure to central nervous system toxin; history of central nervous system infection; metabolic, endocrine, connective tissue disease; hypertension or other cardiovascular disorder; gastrointestinal disorders; abnormal renal, liver or pulmonary function; blood dyscrasias; malignancy; nonstimulant or stimulant pharmacotherapy within 1 month of the study, or any history of antipsychotic medication; neurodegenerative or neurodevelopmental disorder; stroke; epilepsy; sensitivity to flashing lights; subjects requiring regular medication; subjects demonstrated by drug screening to have taken a controlled substance; subjects with a history of hypersensitivity to lidocaine; subjects with IQ less than 80. Females, adolescents and children will be excluded.
Exclusion
Key Trial Info
Start Date :
September 15 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 27 2012
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00397748
Start Date
September 15 2006
End Date
November 27 2012
Last Update
December 16 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892