Status:
TERMINATED
Procalcitonin in Fever of Unknown Etiology
Lead Sponsor:
Changi General Hospital
Conditions:
Fever
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether new blood test (procalcitonin) can help to reduce unnecessary use of antibiotics in patients with unexplained fever. Although fever is most commonly ...
Detailed Description
Antimicrobial resistance has increasingly become a threat to patient safety in health care settings.1 Several studies have identified the inappropriate use of antimicrobials as important risk factor f...
Eligibility Criteria
Inclusion
- All hospitalized patients admitted to general medical or GRM wards with fever and no obvious source of infection, and
- remain febrile after 72 hours of empiric, antimicrobial therapy, and
- initial blood cultures are negative.
Exclusion
- Patients with clinically suspected infection (strongly suggestive symptoms, signs or laboratory/imaging studies) such as pneumonia, urinary tract infection, meningitis, endocarditis, skin and soft tissue infection, etc.
- Confirmed bacterial, viral or fungal infection (positive stain, culture or serology from appropriate clinical specimen).
- Hypotension (systolic blood pressure \<90mmHg)
- Respiratory failure (oxygen requirement \> 4L/min via nasal canula)
- Patients admitted to intensive care unit.
- Severely immunocompromised patients: (febrile neutropenia, HIV infection with CD4 count \< 200, immuno-suppressive therapy).
- Patients younger than 21.
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2007
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00398775
Start Date
January 1 2007
End Date
September 1 2007
Last Update
November 20 2007
Active Locations (1)
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1
Changi General Hospital
Singapore, Singapore, 529889