Status:
TERMINATED
Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide
Lead Sponsor:
Nova Scotia Health Authority
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This study is being done to look at how well people respond to two very different drug treatments for depression. Clinically, people with depression can respond differently to drug treatments for reas...
Detailed Description
Introduction: Bipolar disorder is an illness that consists of distinct episodes or "poles" of both major depression and mania (bipolar I) or major depression and hypomania (bipolar II). Both poles of ...
Eligibility Criteria
Inclusion
- Not currently participating in a drug or medical device clinical trial
- Male or female over the age of 18
- DSM - IV Diagnosis of major depression
- Positive family history of bipolar disorder or completed suicide
Exclusion
- Not able to give informed consent
- Pregnant or breast-feeding
- Current additional psychiatric diagnoses including Panic Disorder, Post -Traumatic Stress Disorder (PTSD) or Psychosis
- History of mania or hypomania
- Active substance abuse or dependence in the last 6 months
- Current depressive episode less than 4 weeks or greater than 12 months in duration
- Current or prior adequate trial of lithium or paroxetine
- Current use of other medications such as antidepressants for the treatment of depression
- Clinically significant medical illness, in particular kidney problems
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT00400088
Start Date
June 1 2007
End Date
January 1 2013
Last Update
January 29 2021
Active Locations (1)
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1
Capital District Health Authority - Dept. of Psychiatry
Halifax, Nova Scotia, Canada, B3H 2E2