Status:
COMPLETED
Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane
Lead Sponsor:
University of Melbourne
Collaborating Sponsors:
Baxter Healthcare Corporation
Conditions:
Coronary Artery Bypass
Delirium
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Background: Different anaesthetic agents have been shown to have different protective effects upon heart, brain and renal function under ischaemic conditions (oxygen starvation). Cardiopulmonary bypas...
Detailed Description
Aims To investigate whether there are differences in postoperative cognitive function, total morbidity or cost, following cardiac surgery determined by the use of either propofol or desflurane as the ...
Eligibility Criteria
Inclusion
- Coronary artery bypass surgery
Exclusion
- Off-pump cardiac surgery
- Require surgery for acute coronary syndrome
- Dialysis dependent renal dysfunction
- Severe liver dysfunction as determined by liver transaminases 1.5X greater than normal.
- Pre-existing diagnosis of schizophrenia, dementia recent stroke or cognitive disorder
- Recent alcohol/drug abuse/intoxication
- Re-do Coronary Artery Grafts
- Coronary Artery Grafts plus other surgery
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
182 Patients enrolled
Trial Details
Trial ID
NCT00400790
Start Date
September 1 2007
End Date
January 1 2010
Last Update
June 29 2010
Active Locations (1)
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1
Royal Melbourne Hospital
Melbourne, Victoria, Australia, 3050