Status:
COMPLETED
Immunity to Human Cholera in Bangladesh
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Cholera
Eligibility:
All Genders
2-60 years
Brief Summary
Cholera is a severe diarrhea illness caused by bacteria. The purpose of this study is to better understand how the immune systems of people in Dhaka, Bangladesh, fight infection with cholera. Understa...
Detailed Description
The purpose of this study is to investigate protective immunity to human cholera in Dhaka, Bangladesh. Immune responses to Vibrio cholerae are poorly understood and have not been extensively studied i...
Eligibility Criteria
Inclusion
- All Participants:
- Men or women age 2 to 60 years, inclusive.
- Provision of informed consent for enrollment in study by patient/parent or guardian, as well as verbal assent for children age 7 to 17 years, inclusive.
- Expressed interest and availability to fulfill the study requirements (index patients for up to 1 year; household contacts up to 30 days).
- Index Patients:
- \- Any individual with cholera enrolled in the surveillance system at the International Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDR,B).
- Household Contacts:
- \- Any household contact of the index patient (defined as sharing the same cooking pot for longer than 3 days before the index patient presented to the ICDDR,B).
- There is no upper limit on the number of household members that can enroll from a single household.
Exclusion
- Clinically apparent severe comorbid condition (meningitis, encephalitis, coma, respiratory distress).
- Concurrent enrollment in an unrelated interventional study.
- For household contacts, living in the same place with an index patient for 3 or fewer days before the index patient presented to the International Centre for Diarrhoeal Diseases Research, Bangladesh.
Key Trial Info
Start Date :
December 11 2006
Trial Type :
OBSERVATIONAL
End Date :
December 31 2012
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT00401934
Start Date
December 11 2006
End Date
December 31 2012
Last Update
January 31 2019
Active Locations (1)
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1
International Centre for Diarrhoeal Disease Research
Dhaka, Bangladesh