Status:
UNKNOWN
DHPLC Determination of TPMT Polymorphisms.
Lead Sponsor:
National Institute of Cancerología
Conditions:
Acute Lymphoblastic Leukemia
Eligibility:
All Genders
18+ years
Brief Summary
TPMT is a key enzyme in the metabolism of thiopurines. TPMT polymorphisms have been described and are associated with a decrease activity of such enzyme. Therefore, a higher risk of developing toxicit...
Detailed Description
Objectives: Determine by DHPLC analysis the frequency of TPMT polymorphisms in mestizos mexican population with acute lymphoblastic leukemia. * To do a clinical correlation between the presence of po...
Eligibility Criteria
Inclusion
- Healthy and patientes with acute lymphoblastic leukemia.
- Age: older than 18 years.
- Attend to the National Institute of Cancerologia
Exclusion
- Foreign patients with an irregular attendance to the National Institute of Cancerologia
Key Trial Info
Start Date :
April 1 2005
Trial Type :
OBSERVATIONAL
End Date :
November 1 2006
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT00402090
Start Date
April 1 2005
End Date
November 1 2006
Last Update
November 22 2006
Active Locations (1)
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1
National Institute of Cancerologia
Mexico City, Mexico City, Mexico, 14080