Status:
COMPLETED
Study to Determine if Taking OTC Non-Steroidal Anti-Inflammatory Affects Eye Pressure in Patients Using Glaucoma Drops
Lead Sponsor:
Philadelphia Eye Associates
Collaborating Sponsors:
Pfizer
Conditions:
Glaucoma
Ocular Hypertension
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
The Purpose of This Study is to Determine if Taking an Over the Counter Non-Steroidal Anti-Inflammatory(Ibuprofen)has an Effect on Eye Pressure in Patients using Brimonidine(Alphagan)and Latanoprost(X...
Detailed Description
Topical IOP-lowering therapy has the advantage of providing a drug level directly to the end organ with very little or no systemic absorption thereby reducing side effect potential. There is very litt...
Eligibility Criteria
Inclusion
- Patients with bilateral or unilateral primary open angle glaucoma or ocular hypertension
- An IOP in each eye of greater than 22mm HG after washout of IOP lowering medications
- No worse than 20/200 best corrected visual acuity
- Normal appearing or non-occludable anterior chamber angles
- Discontinuation of current POAG or OH medications before participation in the study.
- Written Informed Consent
Exclusion
- Use of any other ocular medications
- Previous ocular surgery or laser therapy within the last three months.
- Systemic treatment with any adrenergic agonist or antagonist, corticosteroid or nonsteroidal anti-inflammatory agents(low dose apsirin will be accepted if dose remains the same for entire study period).
- An age of less than 21,of child bearing age and currently pregnant, considering pregnancy or a nursing mother.
- A history of medical noncompliance or unreliability.
- Presence of uncontrolled hypertension, cardiac arrhythmia, cerebrovascular accident, nasal polyps, bleeding diathesis, peptic ulcer disease, gastritis or known intolerance, contraindication or allergy to any drugs used in the study.
- Lactose Intolerance.
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2008
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT00402493
Start Date
December 1 2006
End Date
March 1 2008
Last Update
April 4 2018
Active Locations (3)
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1
Philadelphia Eye Associates
Willingboro, New Jersey, United States, 08046
2
Philadelphia Eye Associates
Philadelphia, Pennsylvania, United States, 19134
3
Philadelphia Eye Associates
Philadelphia, Pennsylvania, United States, 19148