Status:
COMPLETED
Protocol Chronic Obstructive Pulmonary Disease
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Chronic Obstructive Pulmonary Disease
Acute Respiratory Failure
Eligibility:
All Genders
18+ years
Brief Summary
The main objective of the study is to evaluate the predictive factors of the endothelial function to the waning of an acute exacerbation in COPD. It will act to do a multivariate analysis to determine...
Detailed Description
We want to judge the improvement of the endothelial function remotely to the acute exacerbation (6 weeks). And then we would like to correlate this improvement with the variations of oxidative stress,...
Eligibility Criteria
Inclusion
- COPD patients with the waning of exacerbation:
- Male or Female more than 18 years old
- VEF1/FCV \< 70% or COPD already knew
- At the moment of the respiratory failure, the day of the enter in hospital:
- Respiratory frequency \>25
- PaCO2 \> 45 mmHg
- pH \< 7.35
- The day of the inclusion in our study:
- PH \> 7.33 at the end of the respiratory failure, or 2 days of continuation, 3 to 7 days post acute exacerbation of continuation
- Fever \< 38.5
- Patients who have signed the inform consent form
- Stable COPD patients:
- Men or women more than 18 years old
- VEF1/FCV \< 70% or COPD already knew
- Patients who have signed the inform consent form
Exclusion
- Evolutive obvious infection or CRP \> 100 at inclusion Cardiac failure considered like the major cause of the exacerbation or cardiac insufficiency with FEVG \< 45 %
- Smoker \> 10 cigarettes a day Antioxidant catch: N-acetyl-cystein, selenium, ascorbic acid, alpha tocopherol acetate…
- Evolutive neoplasia
- Antioxidant catch: N-acetyl-cystein, selenium, ascorbic acid, alpha tocopherol acetate…
- pregnant women
- patient under supervision or trusteeship
- patient taking part in another clinical trial
- claustrophobia, patients allergic to contrast agents like Gadolinium, presence of material dissuading the realization of a MRI (pacemaker, implantable defibrillator, insulin pump, ferrometallic clips or foreign bodies in brain or eyes)
Key Trial Info
Start Date :
January 11 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 21 2021
Estimated Enrollment :
121 Patients enrolled
Trial Details
Trial ID
NCT00404430
Start Date
January 11 2007
End Date
January 21 2021
Last Update
June 6 2022
Active Locations (1)
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1
France : Laboratoire EFCR - Functional Cardio-Respiratory Exploration Laboratory
Grenoble, Isere, France, 38043