Status:
COMPLETED
The Safety & Efficacy of Combination BMS-201038 (AEGR-733) & Ezetimibe vs. Monotherapy in Moderate Hypercholesterolemia
Lead Sponsor:
Aegerion Pharmaceuticals, Inc.
Conditions:
Hypercholesterolemia
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
The main objectives of this study are to evaluate the efficacy and safety of combination therapy BMS-201038 (AEGR-733) plus ezetimibe vs. each agent given alone on LDL cholesterol and other lipoprotei...
Detailed Description
Subjects will participate in this study for approximately 14-17 weeks. This study has 2 periods: 1) a 1-2-week screening period with 2 visits where baseline cholesterol and other characteristics will ...
Eligibility Criteria
Inclusion
- Men and women between the ages of 18 and 70 years .
- For subjects with 0 to 1 risk factor (cigarette smoking, hypertension (BP \> 140/90 or on antihypertensive medication), low HDL (\<40mg/dl), family history of premature CHD (CHD in male first degree relative \<55 years; CHD in female first degree relative \<65 years), age (men\> 45 years; women \> 55 years): Baseline mean LDL-C must be \>160 and \<250 mg/dl as determined by the arithmetic mean of measures taken at visit 1 and 2. Fasting mean TGs should be \<400 mg/dl.
- For subjects with 2 or more risk factors (cigarette smoking, hypertension (BP \> 140/90 or on antihypertensive medication), low HDL (\<40mg/dl), family history of premature CHD (CHD in male first degree relative \<55 years; CHD in female first degree relative \<65 years), age (men\> 45 years; women \> 55 years) or prior stable CHD: Baseline mean LDL-C must be \>130 and \<250 mg/dl as determined by the arithmetic mean of measures taken at visit 1 and 2. Fasting mean TGs should be \<400 mg/dl.
- Able to understand and willing to comply with all study requirements, particularly the study drug regimen.
- Able to understand and willing to sign the Informed Consent Form.
Exclusion
- Women who are pregnant or lactating or who are planning to become pregnant or women of child bearing potential who have not successfully been using acceptable contraceptive methods over the previous 3 months (e.g. intrauterine device and barrier method plus spermicide).
- Uncontrolled hypertension defined as: systolic blood pressure \> 180 mmHg, diastolic blood pressure \> 95 mmHg
- History of chronic renal insufficiency (serum creatinine \>2.5 mg/dL)
- History of liver disease or transaminases above 1.5 X ULN at screening
- Any major surgical procedure occurring less than 3 months prior to the screening visit
- Cardiac insufficiency defined by the NYHA classification as functional Class II-Class IV
- History of a malignancy (other than basal cell or squamous cell carcinoma of the skin that has been removed) within the previous 5 years
- Participation in an investigational drug study within 6 weeks prior to the screening visit.
- Serious or unstable medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study.
- Regular alcohol use \> 1 drink per day
- Regular consumers of grapefruit juice, or currently taking medications known to be metabolized by CYP 3A4 (cyclosporine, itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, and nefazodone)
- Other lipid-lowering medications (washouts will be permitted)
- Acute CVD (CVD event within the previous 6 months)
- Diabetes Mellitus
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2007
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00405067
Start Date
May 1 2006
End Date
January 1 2007
Last Update
March 4 2014
Active Locations (1)
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1
Pharmanet, Inc
Princeton, New Jersey, United States, 08540-6242