Status:
COMPLETED
Aprotinin Use and Renal Outcome in Hypothermic Bypass and Circulatory Arrest for Surgical Repair of Thoracic Aorta.
Lead Sponsor:
Weill Medical College of Cornell University
Conditions:
Circulatory Arrest
Eligibility:
All Genders
Brief Summary
Primary Objective: The aim of this study is to assess the effects of Aprotinin (an antifibrinolytic drug used to reduce bleeding during cardiac surgery) on renal function in patients undergoing surger...
Detailed Description
Significance: Complex surgery of the ascending thoracic aorta and the aortic arch requires use of cardiopulmonary bypass (CPB) with moderate or profound total body hypothermia and circulatory arrest....
Eligibility Criteria
Inclusion
- Adult male and female patients having surgery of ascending and aortic arch
- Use of Antifibrinolytic agents (Aprotinin and Aminocaproic Acid)
Exclusion
- Emergency surgery for ruptured aorta
- Pre-Existing Renal Failure or Renal dysfunction (creatinine \>2.0 mg/dl)
- Moderate or Severe Ventricular Dysfunction
Key Trial Info
Start Date :
July 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
1250 Patients enrolled
Trial Details
Trial ID
NCT00405093
Start Date
July 1 2006
End Date
May 1 2013
Last Update
January 19 2017
Active Locations (1)
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1
The New York Presbyterian Hospital - Weill Medical College of Cornell University
New York, New York, United States, 10021