Status:
COMPLETED
Effects of Atorvastatin Versus Pravastatin on Platelet Inhibition by Clopidogrel
Lead Sponsor:
Shenyang Northern Hospital
Conditions:
Ischemic Heart Disease
Acute Coronary Syndromes
Eligibility:
All Genders
18-85 years
Phase:
PHASE4
Brief Summary
Clopidogrel and statins are frequently coadministered in patients with ischemic heart diseases. Recent reports suggested that clopidogrel's effectiveness in inhibiting adenosine diphosphate (ADP)-indu...
Eligibility Criteria
Inclusion
- Diagnosed with ACS.
- Between ages of 18 Years and 85 years.
- Presence of one or several stenosis in native coronary arteries requiring PCI.
- Willing and able to sign informed consent.
Exclusion
- A history of bleeding diathesis.
- New York Heart Association functional class IV.
- Prior PCI or coronary bypass grafting \< 3 months.
- Contraindications to statins, clopidogrel and aspirin (White blood cells counts \< 4×109/L or platelet counts \<100 g/l; creatinine clearance \<25 ml/ min; active liver disease).
- Use of glycoprotein IIb/IIIa inhibitors before PCI.
- Use of statins before PCI.
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2008
Estimated Enrollment :
1300 Patients enrolled
Trial Details
Trial ID
NCT00405717
Start Date
February 1 2006
End Date
May 1 2008
Last Update
November 7 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Northern Hospital
Shenyang, Liaoning, China