Status:
COMPLETED
The Effect of Magnesium Sulphate on the Time Course of Rocuronium Induced Neuromuscular Block
Lead Sponsor:
University Hospital, Geneva
Conditions:
Neuromuscular Blockade
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
The aim of this study is to investigate whether an optimized pre-treatment with intravenous magnesium enhances the speed of onset of a standard intubation dose of rocuronium.
Detailed Description
In a previous study pre-treatment with intravenous MgSO4 60 mg kg-1 was not shown to have any impact on the onset of action of rocuronium \[Kussmann et al, 1997\]. Yet, in that study, MgSO4 was inject...
Eligibility Criteria
Inclusion
- American Society of Anaesthesiology (ASA) status I or II
- Adults, aged 18 years to 60 years
- Scheduled for elective surgery lasting longer than 120 min without need for continuous curarisation
Exclusion
- A history of allergy or hypersensitivity to rocuronium
- Neuromuscular disease
- Preoperative medications known to influence neuromuscular function (for instance, certain antibiotics and anticonvulsants)
- Electrolyte abnormalities
- Hepatic or renal insufficiency
- Patients with a body mass index \<19 or \>28 kg m2
- Pregnant or breastfeeding women
- Expected difficult intubation or mask ventilation
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00405977
Start Date
May 1 2006
End Date
August 1 2008
Last Update
September 19 2011
Active Locations (1)
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1
University Hospital of Geneva, Anesthesia Department
Geneva, Canton of Geneva, Switzerland, 1211