Status:
COMPLETED
Immune Response to Varicella Vaccination in Children With Atopic Dermatitis
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Atopic Dermatitis
Eligibility:
All Genders
12-36 years
Brief Summary
Atopic dermatitis (AD) causes people to be susceptible to skin infection and inflammations. The purpose of this study is to determine the immune response to chicken pox vaccine in children with or wit...
Detailed Description
AD is a chronic inflammatory skin disorder characterized by recurrent viral skin infections. Children with AD given the smallpox vaccine could develop a life-threatening condition known as eczema vacc...
Eligibility Criteria
Inclusion
- Parent/guardian has signed informed consent
- Male or female of any race or ethnicity
- 12 to 36 months of age, inclusive
- Healthy subjects with no systemic disorders and subjects with moderate to severe AD including a group of subjects with ADEH+
- Previously vaccinated for varicella by a physician 3 weeks prior to the Study Visit (subjects receiving the vaccine 2-16 weeks prior will also be accepted)
Exclusion
- History of infection with chicken pox
- Oral, intravenous, or intramuscular corticosteroids within 30 days prior to chicken pox immunization
- Asthmatics receiving more than 500 micrograms per day of inhaled budesonide or more than 220 micrograms per day of inhaled fluticasone
- Antiherpes antiviral agents within 7 days prior to immunization
- Suspected immune deficiency or family history of primary immunodeficiency
- History of or active cancer
- Active untreated tuberculosis (TB)
- Respiratory illness at the time of chicken pox vaccination
- Receipt of blood products or chicken pox zoster immune globulin within the last 5 months prior to study entry
Key Trial Info
Start Date :
December 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT00406081
Start Date
December 1 2005
End Date
September 1 2009
Last Update
January 11 2017
Active Locations (2)
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1
National Jewish Health
Denver, Colorado, United States, 80206
2
Children's Hospital Boston
Boston, Massachusetts, United States, 02115