Status:
COMPLETED
Research for Elimination of Lymphatic Filariasis (ICIDR)
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Lymphatic Filariasis
Eligibility:
All Genders
6+ years
Brief Summary
The purpose of this study is to check blood samples for lymphatic filariasis to determine whether the recent Program to Eliminate Lymphatic Filariasis was successful in controlling lymphatic filariasi...
Detailed Description
The purpose of this study is to detect lymphatic filariasis in blood samples to determine whether the recently concluded Program to Eliminate Lymphatic Filariasis has been successful in controlling ly...
Eligibility Criteria
Inclusion
- Gender, minority and child inclusion: Males and females will be included in population-based village studies without regard to race or ethnic group. There is no reason to exclude pregnant women from population-based studies. There is no reason to exclude children from the village/town studies, and they are included. Younger children will be studied in the school surveys (with large numbers per locality) because they are important sentinels for ongoing filariasis transmission.
- Eligibility for the cohort study: Subjects in household surveys with positive immunochromotography test, filarial antigen tests, and negative microfilaria thick blood smears and who took diethylcarbamazine and albendazole during the Egyptian Program to Eliminate Lymphatic Filariasis will be invited to participate in the study. Subjects must be residents of localities that have met the Basic Elimination criterion (community microfilaria prevalence by thick smear less than 1% or antigen prevalence rate less than 2%). Consenting subjects will be screened further by testing a sample of venous blood collected after 9 p.m. for microfilaremia by membrane filtration and by performing an ELISA to quantitate filarial antigenemia in serum. Eligible subjects will have no microfilaremia by smear and antigen levels \> 20 ng/ml.
Exclusion
- Exclusion of children less than 10 years of age from community studies of filarial antigen and microfilaria prevalence is justified because prevalence rates for these parameters are exceedingly low in young children in low transmission areas like Egypt.
Key Trial Info
Start Date :
December 1 2006
Trial Type :
OBSERVATIONAL
End Date :
December 1 2011
Estimated Enrollment :
117500 Patients enrolled
Trial Details
Trial ID
NCT00406627
Start Date
December 1 2006
End Date
December 1 2011
Last Update
September 9 2008
Active Locations (1)
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1
Ain Shams University
Cairo, Egypt, 11566