Status:
COMPLETED
Prospective Randomized Trial Between WBRT Plus SRS Versus SRS Alone for 1-4 Brain Metastases
Lead Sponsor:
Hokkaido University Hospital
Conditions:
Brain Metastasis
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine if WBRT combined with SRS resulted in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death.
Detailed Description
Whole-Brain Radiation Therapy (WBRT) had been a mainstay in the treatment of brain metastases. However, treatment strategy which rely on Stereotactic Radiosurgery (SRS) has becoming popular in Japan. ...
Eligibility Criteria
Inclusion
- 18 years of age or older with 1-4 brain metastases, each with a maximum diameter of no more than 3 cm on contrast-enhanced MRI scans, and were derived from a histologically confirmed systemic cancer, Karnofsky Performance Status (KPS) score of 70 or more
Exclusion
- Patients with metastases from small cell carcinoma, lymphoma, germinoma, and multiple myeloma were excluded.
Key Trial Info
Start Date :
October 1 1999
Trial Type :
OBSERVATIONAL
End Date :
April 1 2005
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT00406835
Start Date
October 1 1999
End Date
April 1 2005
Last Update
December 4 2006
Active Locations (1)
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1
Hokkaido University School of Medicine
Sapporo, Hokkaido, Japan, 060-8638