Status:
COMPLETED
PET Imaging of Brain Amyloid Using [11C]MeS-IMPY
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Alzheimer's Disease
Healthy
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Alzheimer's disease is associated with accumulation in the brain of a protein called amyloid. The purpose of this study is to test the ability of a research drug to measure amyloid in brain using posi...
Detailed Description
Alzheimer's disease (AD) is characterized pathologically by the presence of beta-amyloid plaques in brain. A substantial body of research indicates that the presence of increased beta -amyloid peptide...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy control subjects aged 18-90 years and AD patients aged 50-90, with history/physical exam, ECG, and laboratory tests.
- Informed Consent.
- AD Patients: Mini-Mental State Examination (score greater than or equal to 10).
- AD Patients: Meet NINCDS-ADRDA criteria for probable AD.
- EXCLUSION CRITERIA:
- Current or prior history of any alcohol or drug abuse.
- Severe systemic disease based on history and physical exam.
- Positive result on urine screen for illicit drugs.
- Laboratory tests with clinically significant abnormalities.
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure would exceed the annual limits.
- Pregnancy or breast feeding.
- Claustrophobia.
- Presence of ferromagnetic metal in the body or heart pacemaker.
- History of brain disease other than Alzheimer's disease.
- Unable to lay on one's back for the PET/MRI scan.
Exclusion
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00407576
Start Date
December 1 2006
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892