Status:
COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Healthy
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
In this study we will examine where the radioactive tracer \[11C\]PBR28 is distributed in the body of healthy volunteers to calculate the radiation exposure to organs of the body. We will also test if...
Detailed Description
The peripheral benzodiazepine receptor (PBR) is distinct from central benzodiazepine receptors associated with GABA(A) receptors. Although PBR was initially identified in peripheral organs such as kid...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- All subjects must be healthy and aged 18-65 years.
- EXCLUSION CRITERIA:
- Current psychiatric disease, substance abuse or severe systemic disease based on history and physical exam.
- Laboratory tests with clinically significant abnormalities.
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure including that from this protocol would exceed the guidelines set by the Radiation Safety Committee (RSC).
- Pregnancy and breast feeding.
- Positive HIV test.
- Cannot lie flat for 2 - 3 h.
Exclusion
Key Trial Info
Start Date :
November 28 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 21 2016
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT00407693
Start Date
November 28 2006
End Date
July 21 2016
Last Update
November 19 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892